In Moore4Medical “smart multiwell plate” platforms will be developed to seamlessly integrate multiple organ-on-chip technologies from different manufacturers into existing workflows, comprising:
- A smart multiwell plate that works as an autonomous system. It will contain micropumps and a microfluidic infrastructure that provide perfusion, as well as the electronics to drive the micropumps and integrated readout sensors;
- A high definition electrophysiology (HD e-Phys) multiwell plate to bridge the gap between advanced high electrode count CMOS ASICs and the world of biology and pharma by means of advanced microfluidic fan-out technologies integrated into the well plate;
- A smart multiwell plate lid that can be used in combination with ordinary, as well as the smart multiwell plates. The non-disposable lid contains micropumps and sensors that monitor in situ and in a parallel fashion monitor the medium of cell cultures in incubators.
The proposed platforms will be validated in a realistic setting with relevant cell cultures. The universal nature of the smart multiwell plate will be demonstrated with three different organ-on-chip devices from three different manufacturers.
In an innovation track, sensors and organ-on-chip devices will be developed to ensure continuous innovation by bringing advanced sensing and complex organ and disease models to future smart multiwell plates. Furthermore, the “DEPArray” technology of Menarini for the isolation of 100% pure single live cells from heterogeneous samples will be improved by a dedicated sensing platform for the detection and classification of rare cells, such as, but not limited to circulating tumor cells.
- Organ-on-Chip white paper, an hDMT publication
- Towards an organ-on-chip roadmap, an ORCHID publication
- Impact of organ-on-a-chip technology on pharmaceutical R&D costs, N. Franzen et al. Drug Discovery Today, Volume 24, Issue 9, September 2019, Pages 1720-1724